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BETA GLUCANS

BETA GLUCANS by Rena Davis, MSc Copyright © 2007

Scientific Name(s): Beta glucans (Beta-1, 3-glucan), Beta glycans (Beta-1. 3/1, 6-glycan)

Common Name(s): Beta glycans, Beta glucans

Beta glucans have been studied for more than 30 years and have been found to have immune system stimulant properties. In fact, in the 1980s beta glucans were used to make salmon more disease resistant.

Beta glucans are carbohydrates. They are natural compounds derived from a variety of sources including mushrooms (Lentinula Scientific Names: Aloe vera L., A. perryi Baker (Zanzibar or Socotrine aloe), A. barbadensis Miller (also called A. vera Tournefort ex Linne or A. Vulgaris Lamark Curacao or Barbados aloe), or A. ferox Miller (Cape aloe). A. vera Miller and A vera L. may not be the same species.

Common names: Cape, Zanzibar, Socotrine, Curacao, or Barbados aloe, aloe vera edodes), oats, barley, baker’s yeast, algae, and mannin.

In in vitro testing and in mice studies, beta glucans have demonstrated potential immune response through enhanced ability of natural killer cells and macrophase activity. In mice with experimental colon and skin wounds, beta glucans increased tensile strength of wounds by 42% and increased collagen biosynthesis as well.

An all natural dietary supplement, Norwegian beta glucan is sold as a supplement to boost the immune system and protect against colds and flu. It claims to strengthen the body’s natural ability to fight disease-causing organism due to its molecular structure as it binds specifically to macrophage surfaces, activating the immune system and increasing resistance. In another claim, beta glucans are said to pass through the stomach unchanged, due to their acid-resistant nature. Other product claims include beta glucans’ ability to heal bed sores, nail fungus, and ear infections. Beta glucans in human trial in phase I and Phase II HIV research appear promising, but this still requires confirmation.

References:

1. Yadomae T. Structure & biological activities of fungal beta-1, 30glucans. Yakugaku Zasshi 2000; 120(5): 413-31. (Japanese).

2. http://www.immunehealthsystems.com/learning_center.htm Pengelly A. Medicinal Fungi of the world. Modern Phytotherapist 1996; 1/3-8 [review].

3. Artursson P, et al. Macrophage stimulation with some structurally related disaccharides. Scand J Immunol 1987; 25(3): 245-54.

4. Rios-Hernandez M. et al. Immuno pharmacological studies of beta-1, 3- glucan. Arch med Res 1994; 25 (2): 179-80.

5. Sherwood E. et al. Enhancement of interleukin-1 and interleukin-2 production by soluble glucan. Int. J. ImmunoPharmacol 1987; 9(3): 261-67.

6. Baba H., et al. Rapid tumor regression and induction of tumor-regressing activity in serum by various immune modulating agents. Int. J. ImmunoPharmacol 1986; 8(6): 562-72.

7. Suzuki I, et al. Immuno modulation by orally administered beta glucan in mice. Int. J. ImmunoPharmacol 1989; 11(7): 761-69.

8. Suzuki I, et al. Antitumor and immunomodulation activities of a beta glucan obtained form liquid cultured Grifolafrondosa. Chem Pharm Bull 1989 37(2): 410-13.

9. Portera C., et al. Effect of marcrophage stimulation on collagen biosynthesis in the healing wound. Am Surg 1997; 63(2): 125-31.

10. Levy S. Echinacea, more over; Norwegian Beta glucan is here. Drug Topics 2000 Apr. 17:73.

11. http://www.immunehealthsystems.com/learning_center.htm

12. http://www.immunehealthsystems.com/default1.htm

13. Gordon M. Bihari B. Goolsby E., et al. A placebo – controlled trial of immune modulator, lentinan, in HIV positive patients: a Phase I/II trial. J. Med. 1998; 29:305-330.

 



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